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Use of Parenteral Colistin for the Treatment of Multi-Resistant Gram-Negative Organisms in Major Burn Patients
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To elucidate the therapeutic effect and toxicity of intravenous colistin in the trearment caused by multidrug-resistant (MDR) gram-negative bacteria in patients with severe burn.
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A retrospective review was performed on all the patients admitted to our burn intensive care unit at the Hallym University Hangang Sacred Heart Hospital, Seoul, South Korea, from April 2007 to December 2009. One hundred four courses of intravenous colistin treatment administered to 104 patients were included in the study period.
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One hudred four patients were evaluated in the study. The burnt body surface area was between 5 and 96% (mean 49.7%). Presence of inhalation injury was 35 patients (33.7%), CRRT (continuous renal replace therapy) was 38 patients (36.5%). the mean days of colistin was 15 days (range 4-71 days). The length of ICU (intensive care unit) stay was 49 days (range 7-154 days). Death was 40 patients (38.5%).
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Colistin appears to be relatively safe and effective in trearing major burn patients with infections caused by MDR gram-negative bacteria when no other drug is available. In addition, we did not dound any statistically significant impariment of renal function.
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