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Inhibitory role of peripheral benzodiazepine receptor on the vascular endothelial activations
Ãæ³²ÀÇÀü¿ø »ý¸®Çб³½Ç Àüº´È­, ÁÖÈñ°æ, ÀÌÀ¯¶õ, ÃÖ¼º¾Æ, Á¶ÀºÁ¤, ¹Ú¸í¼ö
[ 2014³â 02¿ù 23ÀÏ 18½Ã 55ºÐ ]

Peripheral benzodiazepine receptor(PBR) is a multi functional protein mainly found on the outer mitochon drial membrane. PBR expression is increased by tumor necrosis factor-a(TNF-a) in endothelial cells.

 

Rotenone, cyclosporine A, and bongkrekic acid suppress TNF-a-induced VCAM-1 expression.

 

Overexpression of PBR inhibits voltage-dependent anion channel-1(VDAC-1) expression and the silencing of PBR increases VDAC-1 expression in endothelial cells.

 

Moreover, TNF-a-induced VACM-1 expression is suppressed by VDAC-1 gene silencing. PBR Overexpression significanfly decreases TNF-a-induced mitochondrial reactive oxygen species and MnSOD expression.

 

These results suggest that PBR can inhibit endothelial activation and this action is related to the inhibition of mitochon drial ROS and/or VDAC-1 expression in endothelial cells.

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