|
¿ÃÇØ ÈÀÌÀÚÀÇÇлó ±âÃÊÀÇÇÐ»ó¿¡ ±èÀÀ±¹ ±³¼ö(ÃæºÏÀÇ´ë »ýÈÇб³½Ç), ÀÓ»óÀÇÇÐ»ó¿¡ ±èÀç¹Î ±³¼ö(Àü³²ÀÇ´ë Á¤½Å°Ç°ÀÇÇб³½Ç), Áß°³ÀÇÇл󿡴 ¼ÛÀç°ü ±³¼ö(¿ï»êÀÇ´ë ½ÉÀå³»°úÇб³½Ç)°¡ °¢°¢ ¼±Á¤µÆ´Ù.
21ÀÏ ´ëÇѹα¹ÀÇÇÐÇѸ²¿ø(ȸÀå Á¤³²½Ä)ÀÌ ÁÖ°üÇϰí Çѱ¹ÈÀÌÀÚÁ¦¾à(´ëÇ¥ÀÌ»ç »çÀå ¿Àµ¿¿í)ÀÌ ÈÄ¿øÇÏ´Â ‘Á¦16ȸ ÈÀÌÀÚÀÇÇÐ»ó’ ¼ö»óÀÚ°¡ ¹ßÇ¥µÆ´Ù.
¸ÕÀú ÃæºÏ´ëÇб³ Àǰú´ëÇÐ »ýÈÇб³½Ç ±èÀÀ±¹ ±³¼ö´Â ¼¼°èÀûÀÎ °úÇзÀÇÇÐ ±¹Á¦ÇмúÁö ‘Science Translational Medicine’¿¡ ¹ßÇ¥ÇÑ ‘Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson’s disease’ ³í¹®À» ÅëÇØ PAK4 ÀλêÈ È¿¼Ò°¡ ÇÙ ³»ÀÇ Àü»çÀÎÀÚ¸¦ Á¶ÀýÇÏ´Â ÀλêÈ È¿¼Ò·Î¼ ´Ù¾çÇÑ »ý¹°ÇÐÀû Çö»ó°ú Áúº´¿¡ °ü·ÃµÆÀ½À» ¼Ò°³Çß´Ù.
±è ±³¼ö´Â PAK4°¡ ÁøÇàµÈ Àü¸³¼±¾ÏÀÇ ÁÖ¿ä Ä¡·á Ç¥ÀûÀÓÀ» óÀ½ Á¦½ÃÇß´Ù. ÇâÈÄ PAK4¿¡ ±â¹ÝÀ» µÐ À¯ÀüÀÚ Ä¡·á¸¦ ÆÄŲ½¼º´ÀÇ Ä¡·á¿¡ Àû¿ëÇÒ ¼ö ÀÖ´Â °¡´É¼ºÀ» ¿¾ú´Ù.
±×´Â ÀÌ¿Í °°ÀÌ PAK4ÀÇ ½ÅÈ£Àü´Þ°è¿¡ ´ëÇÑ ÀÏ·ÃÀÇ ±âÃÊ¿¬±¸¸¦ ÅëÇØ ´Ù¾çÇÑ Áúº´À» Á¦¾îÇÒ ¼ö ÀÖ´Â ±âƲÀ» Á¦°øÇÑ ¾÷ÀûÀ» ÅëÇØ ±âÃÊÀÇÇлó ¼ö»óÀÇ ¿µ¿¹¸¦ ¾È¾Ò´Ù.
ÀÓ»óÀÇÇлó ¼ö»óÀÚÀÎ Àü³²´ëÇб³ Àǰú´ëÇÐ Á¤½Å°Ç°ÀÇÇб³½Ç ±èÀç¹Î ±³¼ö´Â ÀÇÇÐ ºÐ¾ßÀÇ ±ÇÀ§ ÇмúÁö ‘Journal of the American Medical Association’¿¡ ¹ßÇ¥ÇÑ ‘Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients with Acute Coronary Syndrome: A Randomized Clinical Trial’ ³í¹®À» ÅëÇØ ½ÉÀåÁúȯ¿¡ µ¿¹ÝµÈ ¿ì¿ïÁõÀ» ¼º°øÀûÀ¸·Î Ä¡·áÇÏ¸é ½ÉÀåÁúȯÀÇ Àå±â ¿¹Èİ¡ ÀÇ¹Ì ÀÖ°Ô °³¼±µÈ´Ù´Â °á·ÐÀ» µµÃâÇß´Ù.
±è ±³¼ö´Â 12³â°£ÀÇ Àå±âÀûÀÎ ÄÚȣƮ ¿¬±¸¸¦ ÅëÇØ, Á¤½Å°ú »Ó¸¸ ¾Æ´Ï¶ó ¼øÈ¯±â ³»°ú Àӻ󰡵鿡°Ô ½ÉÀåÁúȯ µ¿¹Ý ¿ì¿ïÁõ ȯÀÚµéÀ» ¼º°øÀûÀ¸·Î Ä¡·áÇÒ ¼ö Àִ ǥÁØÁø·á±â¼úÀ» Á¦½ÃÇß´Ù.
¿ï»ê´ëÇб³ Àǰú´ëÇÐ ³»°úÇб³½Ç ¼ÛÀç°ü ±³¼ö´Â ¹Ì±¹½ÉÀåÇÐȸ ±ÇÀ§ ÇмúÁö ‘Circulation’¿¡ ¹ßÇ¥ÇÑ ‘Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulin-Like Growth Factor-1 Signaling in Valvular Interstitial Cells’ ³í¹®À» ÅëÇØ ÃÖ±Ù ºü¸¥ ¼Óµµ·Î ÁøÇàµÇ´Â °í·ÉÈ »çȸ¿¡¼ À¯º´·üÀÌ ±Þ°ÝÈ÷ Áõ°¡ÇÏ´Â ´ëµ¿¸ÆÆÇ¸·ÇùÂøÁõ(Calcific Aortic Valve Disease, CAVD)ÀÇ ¹ßº´±âÀüÀ» ¹àÈ÷°í À̸¦ ±â¹ÝÀ¸·Î ³»°úÀû Ä¡·áÀÇ °¡´É¼ºÀ» Á¦½ÃÇß´Ù.
¼Û ±³¼ö´Â ÇØ´ç ¿¬±¸¸¦ ÅëÇØ ÆÇ¸·¼®È¸ÈÀÇ ±âÀüÀ» ¹àÈ÷°í, ±âÁ¸ ´ç´¢º´ Ä¡·áÁ¦·Î ÀÌ¿ëµÇ°í ÀÖ´Â DPP-4 inhibitor¸¦ ÀÌ¿ëÇÒ °æ¿ì CAVDÀÇ ¹ß»ýÀÌ È¿°úÀûÀ¸·Î ¾ïÁ¦µÊÀ» ÀÔÁõÇÑ °ø·Î¸¦ ÀÎÁ¤ ¹Þ¾Æ Áß°³ÀÇÇлó ¼ö»óÀÇ ¿µ±¤À» ¾È¾Ò´Ù.
½Ã»ó½ÄÀº ¿À´Â 11¿ù 7ÀÏ °³ÃֵȴÙ. ¼ö»óÀÚ¿¡°Ô´Â °¢ ºÎ¹®º° 3000¸¸¿ø(ÃÑ 9000¸¸¿ø)ÀÇ »ó±Ý°ú »óÆÐ°¡ ¼ö¿©µÈ´Ù.
±¹³» ÃÖ°í ±ÇÀ§ÀÇ ÀÇÇлóÀÎ ÈÀÌÀÚÀÇÇлó(Pfizer Medical Research Award)Àº ´ëÇѹα¹ ÀÇÇйßÀü ¹× ÀηùÀÇ °Ç°°ú º¹Áö¿¡ ±â¿©ÇÑ ÀÇÇÐÀÚ¸¦ ¹ß±¼Çϰí ÀÇ·á°èÀÇ ¿¬±¸ÀÇ¿åÀ» °íÃëÇϱâ À§ÇØ Áö³ 1999³â¿¡ Á¦Á¤µÆ´Ù.
´ëÇѹα¹ÀÇÇÐÇѸ²¿ø Á¤³²½Ä ȸÀåÀº “Áö¼ÓÀûÀÎ ¿¬±¸¾÷Àû ¹ß±¼À» ÅëÇØ ±¹³» ÀǰúÇÐÀÚµéÀÇ °ø·Î¸¦ µå³ôÀÌ°í »õ·Î¿î Ä¡·á¹ýÀ» Á¦½Ã, Çѱ¹ ÀÇÇÐ°è ¹ßÀü¿¡ ´õ¿í ±â¿©ÇÒ ¼ö Àֱ⸦ ¹Ù¶õ´Ù”°í ÀüÇß´Ù.
Çѱ¹ÈÀÌÀÚÁ¦¾à ¿Àµ¿¿í ´ëÇ¥ÀÌ»ç »çÀåÀº “ÈÀÌÀÚÀÇÇлóÀ» ÅëÇØ ±¹³» ÀǰúÇÐÀÚµéÀÇ ¿¬±¸Àǿ带 °íÃë½Ã۰í ÀÇÇÐ ¹ßÀü¿¡ ±â¿©ÇÒ ¼ö ÀÖ¾î ¶æ ±í°Ô »ý°¢ÇÑ´Ù”¸é¼ “±¹³» ÀÇÇÐ°è ¹ßÀü¿¡ °øÇåÇϱâ À§ÇØ Áö¼ÓÀûÀ¸·Î ³ë·ÂÇϰڴٔ°í ¸»Çß´Ù.
|